361552

GSK-3 Inhibitor IX

InSolution, ≥97%

• Synonyme(s) : InSolution GSK-3 Inhibitor IX
• Formule empirique (notation de Hill) : C₁₆H₁₀BrN₃O₂
• Numéro CAS: 667463-62-9
• Poids moléculaire : 356.17
• Numéro MDL: MFCD08705318
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Chaîne SMILES: Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2
• InChI: 1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,14,18H,(H,19,21)/b15-13-
• Clé InChI: WFRDXNRAUPBBTO-SQFISAMPSA-N

Description

Description générale

A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Specificity was confirmed using various Cdk′s (IC₅₀ = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC₅₀ ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).

Actions biochimiques/physiologiques

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target IC₅₀: 5 nM against GSK-3α/β

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Forme physique

A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.

Autres remarques

Polychronopoulos, P., et al. 2004. J. Med. Chem.47, 935.
Sato, N., et al. 2004. Nat. Med.10, 55.
Meijer, L., et al. 2003. Chem. Biol.10, 1255.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 188.6 °F
• Point d'éclair (°C): 87 °C