345749
GDF-8 Propeptide, His•Tag®, Mouse, Recombinant
GDF-8 Propeptide, His•Tag, Mouse, Recombinant, consists of amino acids 25-285, fused at the C-terminus to a His•Tag sequence, and expressed in NS0-derived mouse myeloma cells.
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About This Item
Code UNSPSC :
12352203
Produits recommandés
Produit recombinant
expressed in mouse NSO cells (myeloma cells)
Niveau de qualité
Pureté
≥90% (SDS-PAGE)
Forme
lyophilized
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
Impuretés
≤1.0 EU/μg protein Endotoxin
Conditions d'expédition
ambient
Température de stockage
−20°C
Description générale
Recombinant, mouse growth differentiation factor-8 (GDF-8)/myostatin propeptide, consisting of amino acids 25-285, fused at the C-terminus to a His•Tag sequence, and expressed in NS0-derived mouse myeloma cells. GDF-8 is a secreted protein that is expressed during embryonic development and in adult skeletal muscle.
Application
GDF-8 Propeptide, His•Tag, Mouse, Recombinant, consists of amino acids 25-285, fused at the C-terminus to a His•Tag sequence, and expressed in NS0-derived mouse myeloma cells.
Actions biochimiques/physiologiques
ED₅₀ = 0.05-0.25 µg/ml (using 40 ng/ml rmGDF-8) as measured by inhibition of rmGDF-8 activity in K562 human chronic myelogenous leukemia cells. Approximately 1 µg/ml will completely inhibit GDF-8 activity in K562 cells.
Avertissement
Toxicity: Standard Handling (A)
Forme physique
Lyophilized from 0.2 µm filtered PBS, BSA.
Reconstitution
Following reconstituyion refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
Reconstitute to 50 µg/ml with sterile PBS containing ≥1% human or bovine serum albumin.
Autres remarques
Hill, J.J. et al. 2003. Molecular Endocrinology17, 1144.
Thies, R.S. et al. 2001. Growth Factors18, 251.
Chang, H. et al. 2002. Endocrine Reviews23, 787.
McPherron, A.C. et al. 1997. Nature387, 83.
Thies, R.S. et al. 2001. Growth Factors18, 251.
Chang, H. et al. 2002. Endocrine Reviews23, 787.
McPherron, A.C. et al. 1997. Nature387, 83.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 2
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