344847

Fumitremorgin C, Aspergillus. fumigatus

A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity.

• Synonyme(s) : Fumitremorgin C, Aspergillus. fumigatus, NSC719655, FTC
• Formule empirique (notation de Hill): C₂₂H₂₅N₃O₃
• Numéro CAS: 118974-02-0
• Poids moléculaire : 379.45
• Numéro MDL: MFCD08702652
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: lyophilized
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Solubilité: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C22H25N3O3/c1-12(2)9-18-20-15(14-7-6-13(28-3)10-16(14)23-20)11-19-21(26)24-8-4-5-17(24)22(27)25(18)19/h6-7,9-10,17-19,23H,4-5,8,11H2,1-3H3/t17-,18-,19-/m0/s1
• Clé InChI: DBEYVIGIPJSTOR-FHWLQOOXSA-N

Description

Description générale

A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity. Also acts as a potent and specific chemosenzitizing agent.

A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits the ATPase and multidrug resistance activity of BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) without affecting the activity of MDR1. Also acts as a potent and specific chemosenzitizing agent. Suggested concentration for cell inhibition studies: ~1-5 µM.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2)

Product does not compete with ATP.

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Allen, J.D., et al. 2002. Mol. Cancer Ther.1, 417.
Ozvegy, C., et al. 2001. Biochem. Biophys. Res. Commun.285, 111.
Rabindran, S.K., et al. 2000. Cancer Res.60, 47.
Rabindran, S.K., et al. 1998. Cancer Res.58, 5850.
Cole, R.J., et al. 1977. J. Agric. Food Chem.25, 826.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable