191501

1-Azakenpaullone

InSolution, ≥94%, ATP-competitive inhibitor of GSK-3Beta

• Synonyme(s) : InSolution 1-Azakenpaullone
• Formule empirique (notation de Hill): C₁₅H₁₀BrN₃O
• Numéro CAS: 676596-65-9
• Poids moléculaire : 328.16
• Numéro MDL: MFCD09037522
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥94% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• InChI: 1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
• Clé InChI: NTSBZVCEIVPKBJ-UHFFFAOYSA-N

Description

Description générale

A Kenpaullone (>Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC₅₀ = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC₅₀ = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
GSK-3β

Reversible: yes

Target IC₅₀: 18 nM for GSK-3&beta

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Forme physique

A 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.

Autres remarques

Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 188.6 °F - (refers to pure substance)
• Point d'éclair (°C): 87 °C - (refers to pure substance)