178220

Antipain, Hydrochloride

Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes.

• Synonyme(s) : Antipain, Hydrochloride
• Formule empirique (notation de Hill): C₂₇H₄₄N₁₀O₆ · xHCl
• Numéro CAS: 37682-72-7
• Poids moléculaire : 604.70 (free base basis)
• Numéro MDL: MFCD00135957
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white to slightly yellowish
• Solubilité: water: 10 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1
• Clé InChI: GXQPAKIVOCLCHD-BXLPLHKWSA-N

Description

Description générale

Effective concentration: 1-100 µM.

Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca²⁺-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC₅₀ = 300 µM).

Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca²⁺-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain, and some cysteine proteases (IC₅₀ ~500 ng/ml). Effective at concentrations of 1-100 µM.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Trypsin-like serine proteases

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 300 µM against trypsin-like serine proteases, papain and some cysteine proteases

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Autres remarques

Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Umezawa, H. 1976. Methods Enzymol.55, 678.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable