1.37037

Guanidine hydrochloride

EMPROVE^® EXPERT, NF

• Synonyme(s) : Aminoformamidine hydrochloride, Aminométhanamidine hydrochloride, Chlorure de guanidinium
• Formule linéaire : NH₂C(=NH)NH₂ · HCl
• Numéro CAS: 50-01-1
• Poids moléculaire : 95.53
• Numéro Beilstein : 3591990
• Numéro MDL: MFCD00013026
• Code UNSPSC : 12352107
• Numéro de classement CE : 200-002-3

Propriétés

• Agence: NF
• Niveau de qualité: 500
• Gamme de produits: EMPROVE^® EXPERT
• Puissance: 655.3-907.1 mg/kg LD₅₀, oral (Rat); >2000 mg/kg LD₅₀, skin (Rabbit)
• Caractéristiques: RNase and DNase free
• pH: 4.5-5.5 (20 °C, 100 g/L in H₂O)
• Pf: 180-185 °C (lit.); 188 °C
• Solubilité: 2150 g/L
• Densité: 1.3 g/cm³ (lit.)
• Masse volumique apparente: 550‑620 kg/m³
• Température de stockage: 2-30°C
• Chaîne SMILES: Cl[H].NC(N)=N
• InChI: 1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
• Clé InChI: PJJJBBJSCAKJQF-UHFFFAOYSA-N

Description

Description générale

Finding the right chemical that matches your pharma and biopharma manufacturing needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for pharma and biopharma manufacturing withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Our SAFC^® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our EMPROVE^® Program, our raw materials are offered with EMPROVE^® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Application

Agent fortement chaotropique permettant de dénaturer puis de replier les protéines. Ce dénaturant puissant peut solubiliser les protéines insolubles ou dénaturées telles que les corps d'inclusion. Il peut servir de première étape dans le repliement sous forme active des protéines ou des enzymes. Il peut être également nécessaire d'utiliser de l'urée et du dithiothréitol (DTT).

Autres remarques

Due to its low microbial and endotoxin limits, Guanidinium chloride Emprove^® Expert is suitable for biopharma manufacturing needs.

Informations légales

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302 + H332 - H315 - H319
• Conseils de prudence: P261 - P264 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable