124038

Akt Inhibitor V, Triciribine

InSolution, ≥95%

• Synonyme(s) : InSolution Akt Inhibitor V, Triciribine
• Formule empirique (notation de Hill): C₁₃H₁₆N₆O₄
• Numéro CAS: 35943-35-2
• Poids moléculaire : 320.30
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Conditions d'expédition: ambient
• Température de stockage: −70°C
• InChI: 1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
• Clé InChI: HOGVTUZUJGHKPL-HTVVRFAVSA-N

Description

Description générale

A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Forme physique

A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.

Reconstitution

Following intitial thaw, aliquot and freeze (-70°C).

Autres remarques

Karst, A., et al. 2006. Cancer Res.66, 9225.
Yang, L., et al. 2004. Cancer Res.64, 4394.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany