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Principaux documents

07-617

Sigma-Aldrich

Anti-mGluR1 Antibody

Upstate®, from rabbit

Synonyme(s) :

Anti-GPRC1A, Anti-MGLU1, Anti-MGLUR1, Anti-PPP1R85, Anti-SCA44, Anti-SCAR13

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

rat

Fabricant/nom de marque

Upstate®

Technique(s)

western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... GRM1(2911)

Spécificité

Predicted to cross-react with human and mouse based on sequence homology
mGluR1

Immunogène

peptide corresponding to amino acids 1180-1199 (C-PNVTYASVILRDYKQSSSTL) of rat mGluR1

Application

Anti-mGluR1 Antibody detects level of mGluR1 & has been published & validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Neurodegenerative Diseases

Qualité

routinely evaluated by immunoblot on mGluR1 in rat brain microsomal preparation

Description de la cible

142kDa

Forme physique

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
Format: Purified
Protein A purified

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1


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Consulter la Bibliothèque de documents

F Ango et al.
Nature, 411(6840), 962-965 (2001-06-22)
G-protein-coupled receptors (GPCRs) transduce signals from extracellular transmitters to the inside of the cell by activating G proteins. Mutation and overexpression of these receptors have revealed that they can reach their active state even in the absence of agonist, as
M Sallese et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(15), 2569-2580 (2000-12-02)
G-protein-coupled receptor kinases (GRKs) are involved in the regulation of many G-protein-coupled receptors. As opposed to the other GRKs, such as rhodopsin kinase (GRK1) or beta-adrenergic receptor kinase (beta ARK, GRK2), no receptor substrate for GRK4 has been so far
D D Wright et al.
The Journal of comparative neurology, 364(4), 729-745 (1996-01-22)
We demonstrate that the metabotropic glutamate receptor mGluR1 alpha is enriched in two interneuron cell populations in the dorsal division of the cochlear nucleus. Electron microscopic analysis confirms that mGluR1 alpha immunoreactivity is concentrated in the dendritic spines of cartwheel
Glutamate and the glutamate receptor system: a target for drug action.
Bleich, Stefan, et al.
International Journal of Geriatric Psychiatry, 18, S33-S40 (2003)
L B Dale et al.
The Journal of biological chemistry, 275(49), 38213-38220 (2000-09-13)
Metabotropic glutamate receptors (mGluRs) constitute a unique subclass of G protein-coupled receptors (GPCRs) that bear little sequence homology to other members of the GPCR superfamily. The mGluR subtypes that are coupled to the hydrolysis of phosphoinositide contribute to both synaptic

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