07-546
Anti-ADAP/SLAP-130/Fyb Antibody
Upstate®, from rabbit
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
purified antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
mouse
Fabricant/nom de marque
Upstate®
Technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
Isotype
IgG
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... FYB(2533)
Spécificité
ADAP/SLAP-130/Fyb
Immunogène
synthetic peptide corresponding to amino acids 755-768 of mouse Fyn binding protein (ADAP/SLAP-130/Fyb)
Application
Anti-ADAP/SLAP-130/Fyb Antibody is an antibody against ADAP/SLAP-130/Fyb for use in WB & IP.
Research Category
Signaling
Signaling
Research Sub Category
Immunological Signaling
Kinases & Phosphatases
Immunological Signaling
Kinases & Phosphatases
Qualité
routinely evaluated by immunoblot in RIPA lysates from RAW 264.7 macrophage cells
Description de la cible
130kDa
Forme physique
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein A purified
Stockage et stabilité
2 years at -20°C
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
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Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
Rajasekaran, K; Kumar, P; Schuldt, KM; Peterson, EJ; Vanhaesebroeck, B; Dixit, V; Thakar et al.
Nature Immunology null
A J Hunter et al.
Journal of immunology (Baltimore, Md. : 1950), 164(3), 1143-1147 (2000-01-21)
The role of integrin-mediated signaling events in T cell function remains incompletely characterized. We report here that alpha4beta1 integrin stimulation of H9 T cells and normal human T cell blasts results in rapid and transient tyrosine phosphorylation of the adapter
L Geng et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(20), 11527-11532 (2001-09-13)
Aggregation of the high-affinity IgE receptor (FcepsilonRI) on mast cells activates a tyrosine phosphorylation cascade that is required for adhesion and degranulation events leading to the release of histamine and other inflammatory mediators. The full range of intracellular mediators that
N J Boerth et al.
The Journal of biological chemistry, 275(7), 5143-5152 (2000-02-15)
T cell antigen receptor (TCR) engagement results in protein-tyrosine kinase activation which initiates signaling cascades leading to induction of the interleukin-2 gene. Previous studies identified two substrates of the TCR-induced protein-tyrosine kinases, SH2 domain-containing leukocyte specific protein of 76 kDa
Chunyang Li et al.
EMBO molecular medicine, 7(6), 754-769 (2015-04-09)
PD-1 negatively regulates CD8(+) cytotoxic T lymphocytes (CTL) cytotoxicity and anti-tumor immunity. However, it is not fully understood how PD-1 expression on CD8(+) CTL is regulated during anti-tumor immunotherapy. In this study, we have identified that the ADAP-SKAP55 signaling module
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