06-570-AF488
Anti-phospho Histone H3 (Ser10) Antibody, Alexa Fluor™ 488 Conjugate
from rabbit, ALEXA FLUOR™ 488
Synonyme(s) :
H3S10P, Histone H3 (phospho Ser10), H3 histone, family 3A, H3.3A, H3 histone, family 3B, H3.3B
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
ALEXA FLUOR™ 488
Forme d'anticorps
purified antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
human, mouse
Technique(s)
immunocytochemistry: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
phosphorylation (pSer10)
Informations sur le gène
human ... HIST1H3F(8968)
Description générale
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
Immunogène
Linear peptide corresponding to phospho-Histone H3 (Ser10).
Application
Anti-phospho-H3 (Ser10), Alexa Fluor™ 488 Conjugate is a purified rabbit polyclonal that detects Histone H3 phosphorylated at serine 10. This Ab is labeled with Alexa Fluor 488 and validated in IC. The unconjugated version of this antibody is highly published and proven in ICC, IP & WB.
Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected phospho Histone H3 (Ser10) in NIH/3T3 cells.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Histone H3 (Ser10) in HeLa cell lysate.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Histone H3 (Ser10) in HeLa cell lysate.
Research Category
Epitope Tags & General Use
Epitope Tags & General Use
Research Sub Category
Epitope Tags
Epitope Tags
Qualité
Evaluated by Immunocytochemistry in HeLa cells.
Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected phospho Histone H3 (Ser10) in HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected phospho Histone H3 (Ser10) in HeLa cells.
Alexa Fluor™ is a registered trademark of Life Technologies.
Description de la cible
~17 kDa observed
Forme physique
Protein A purified
Purified rabbit conjugate in buffer containing PBS, 15 mg/ml BSA, and 0.1% Sodium Azide.
Stockage et stabilité
Stable for 1 year at 2-8°C from date of receipt.
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
ALEXA FLUOR is a trademark of Life Technologies
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Zoe L Grant et al.
The Journal of clinical investigation, 130(8), 4235-4251 (2020-05-20)
Aberrant, neovascular retinal blood vessel growth is a vision-threatening complication in ischemic retinal diseases. It is driven by retinal hypoxia frequently caused by capillary nonperfusion and endothelial cell (EC) loss. We investigated the role of EC apoptosis in this process
Matheus H Dias et al.
Molecular oncology, 13(2), 290-306 (2018-11-14)
In malignant transformation, cellular stress-response pathways are dynamically mobilized to counterbalance oncogenic activity, keeping cancer cells viable. Therapeutic disruption of this vulnerable homeostasis might change the outcome of many human cancers, particularly those for which no effective therapy is available.
Haley Jeanette et al.
Glia, 69(4), 1061-1074 (2020-12-19)
YAP and TAZ are effectors of the Hippo pathway that controls multicellular development by integrating chemical and mechanical signals. Peripheral nervous system development depends on the Hippo pathway. We previously showed that loss of YAP and TAZ impairs the development
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