04-262
Anti-Ubiquitinylated proteins Antibody, clone FK1
clone FK1, Upstate®, from mouse
Synonyme(s) :
Anti-Ubiquitin Antibody
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
FK1, monoclonal
Réactivité de l'espèce (prédite par homologie)
all
Fabricant/nom de marque
Upstate®
Technique(s)
immunohistochemistry: suitable
western blot: suitable
Isotype
IgM
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Description générale
Ubiquitin is a polypeptide of 76 amino acid residues, being a very highly conserved and widely distributed protein in all eukaryotic cells. It has been proposed that ubiquitin plays important roles in various biological processes such as the regulation of cell cycle, DNA replication, DNA repair, stress response, apoptosis, signal transduction, and the biogenesis of ribosome, nucleosome, peroxisome and myofibrils. In these processes, ubiquitin functions as both a signal for protein degradation and as a chaperone promoting the formation of organelles.
Spécificité
Recognizes only poly-ubiquitinylated proteins and not mono-ubiquitinylated proteins or free ubiquitin.
Immunogène
Poly-ubiquitinylated-lysozyme.
Application
Anti-Ubiquitinylated proteins Antibody, clone FK1 is an antibody against Ubiquitinylated proteins for use in WB, IH.
Research Category
Protein Trafficking
Protein Trafficking
Research Sub Category
Ubiquitin & Ubiquitin Metabolism
Ubiquitin & Ubiquitin Metabolism
Forme physique
100 µL of concentration 1mg/mL purified immunoglobulin in PBS containing 0.1% sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Format: Purified
Stockage et stabilité
Stable for 1 year at 2-8°C from date of shipment for up to 12 months.
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Chris McKinnon et al.
Acta neuropathologica, 131(3), 411-425 (2015-12-10)
Prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of misfolded prion protein (PrP(Sc)) in the brain. The critical relationship between aberrant protein misfolding and neurotoxicity currently remains unclear. The accumulation of aggregation-prone proteins has been
Kaisa Haglund et al.
Nature cell biology, 5(5), 461-466 (2003-04-30)
Many cellular proteins are post-translationally modified by the addition of a single ubiquitin or a polyubiquitin chain. Among these are receptor tyrosine kinases (RTKs), which undergo ligand-dependent ubiquitination. The ubiquitination of RTKs has become recognized as an important signal for
Hugues Lelouard et al.
Nature, 417(6885), 177-182 (2002-05-10)
Dendritic cells (DCs) are antigen-presenting cells with the unique capacity to initiate primary immune responses. Dendritic cells have a remarkable pattern of differentiation (maturation) that exhibits highly specific mechanisms to control antigen presentation restricted by major histocompatibility complex (MHC). MHC
z-Leucinyl-leucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.
Monticone M, Biollo E, Fabiano A, Fabbi M, Daga A, Romeo F, Maffei M, Melotti A et al.
Molecular Cancer Research null
Miao Li et al.
Methods in molecular biology (Clifton, N.J.), 1436, 85-94 (2016-06-02)
Histone deacetylase 6 (HDAC6) is a member of class IIb HDAC family. HDAC6 exists predominantly in the cytoplasm and deacetylates mainly non-histone proteins in the cytoplasm. Via its deacetylase and ubiquitin binding domains, HDAC6 regulates microtubules, cytoskeleton, intracellular trafficking, and
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