N-100

Norchlordiazepoxide solution

1.0 mg/mL (Acetonitrile:DMSO (80:20)(v/v)), ampule of 1 mL, certified reference material, Cerilliant^®

• Formule empirique (notation de Hill): C₁₅H₁₂ClN₃O
• Numéro CAS: 7722-15-8
• Poids moléculaire : 285.73
• Numéro MDL: MFCD27976665
• Code UNSPSC : 41116107
• ID de substance PubChem : 329818475
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: liquid
• Caractéristiques: (Snap-N-Spike^®)
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 1.0 mg/mL (Acetonitrile:DMSO (80:20)(v/v))
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): clinical testing
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: ClC1=CC2=C(N=C(N)C[N+]([O-])=C2C3=CC=CC=C3)C=C1
• InChI: 1S/C15H12ClN3O/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)19(20)9-14(17)18-13/h1-8H,9H2,(H2,17,18)
• Clé InChI: LNLMGKOHYYEWMY-UHFFFAOYSA-N

Description

Description générale

Norchlordiazepoxide is a major urinary metabolite of the benzodiazepine chlordiazepoxide, indicated for short term treatment of severe anxiety and for the management of acute alcohol withdrawal syndrome. The metabolite, also known as N-desmethylchlordiazepoxide, is pharmacologically active. This Certified Spiking Solution^® is suitable for GC/MS or LC/MS methods in chlordiazepoxide testing for forensic analysis, urine drug testing, or clinical toxicology.

Application

• Immunoassay detection of benzodiazepines: A study assessed the efficacy of immunoassays in detecting benzodiazepines and their metabolites in blood, including Norchlordiazepoxide. This research is vital for clinical toxicology and forensic applications, providing essential insights into drug monitoring and abuse detection (Huang & Moody, 1995).


• High-performance liquid chromatographic method: A method for determining clonazepam and other benzodiazepines in serum was developed, applicable to Norchlordiazepoxide. This technique underscores the compound′s clinical relevance and enhances pharmacokinetic and therapeutic drug monitoring (Haver et al., 1986).


• Photolytic derivatization for LCEC: Research highlighted the use of photolytic derivatization to improve the determinations of pharmaceuticals, including benzodiazepines like Norchlordiazepoxide, in biological fluids. This study contributes to the advancements in analytical chemistry, improving the accuracy of drug level assessments (Selavka et al., 1985).


• Postmortem stability of benzodiazepines: An investigation into the postmortem stability of benzodiazepines in blood and tissues provided critical data for forensic sciences, particularly regarding the stability of compounds like Norchlordiazepoxide after death, aiding in legal and medical examinations (Levine et al., 1983).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H302 + H312 + H332,H319
• Conseils de prudence: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): 35.6 °F - closed cup
• Point d'éclair (°C): 2.0 °C - closed cup