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E-081

Supelco

Etizolam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formule empirique (notation de Hill) :
C17H15ClN4S
Numéro CAS:
40054-69-1
Poids moléculaire :
342.85
Numéro MDL:
MFCD00867532
Code UNSPSC :
41116107
ID de substance PubChem :
329798867
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Forme

liquid

Caractéristiques

(Snap-N-Spike®)

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland)

Concentration

1.0 mg/mL in methanol

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

clinical testing

Format

single component solution

Température de stockage

−20°C

Chaîne SMILES 

CCC1=CC2=C(S1)N3C(CN=C2C4=CC=CC=C4Cl)=NN=C3C

InChI

1S/C17H15ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h4-8H,3,9H2,1-2H3

Clé InChI

VMZUTJCNQWMAGF-UHFFFAOYSA-N

Catégories apparentées

Description générale

A certified solution standard for use in LC/MS or GC/MS benzodiazepine testing methods in clinical toxicology, urine drug testing, or forensic analysis. Etizolam, sold under brand names such as Etilaam, Etizola, or Depas, is a benzodiazepine analog used for the short-term treatment of insomnia, anxiety, or panic attacks. Etizolam is also sold on the designer drug market with cases of abuse noted in Europe and the US.

Actions biochimiques/physiologiques

Etizolam is a thienodiazepine anxiolytic and as compared to other benzodiazepines has lower dependence potential. It differs from other benzodiazepines in that its molecules possess a thiophene ring instead of benzene. It has anticonvulsant, sedative, anxiolytic, amnesic, hypnotic and muscle relaxant properties. It′s mode of action is through benzodiazepine receptor. It is used to treat insomnia, moderate depression and social anxiety disorder, and has occasionally been associated with blepharospasm and skin lesions.

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

49.5 °F

Point d'éclair (°C)

9.7 °C

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Certificats d'analyse (COA)

Lot/Batch Number

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Encyclopedia of Psychopharmacology
Ian Stolerman
Springer Science & Business Media, 502-502 (2010)
Sumit Gupta et al.
Indian journal of pharmacology, 46(6), 655-656 (2014-12-30)
Etizolam is a thienodiazepine anxiolytic which is said to have lower dependence potential than other benzodiazepines. We report a case of etizolam dependence in a young male with social anxiety disorder and moderate depression. This case report highlights the fact
Toshiaki Makino et al.
Biological & pharmaceutical bulletin, 28(2), 280-284 (2005-02-03)
Kamisyoyosan (KSS) and Tokisyakuyakusan (TSS) are widely used herbal formulas in Japanese traditional kampo medicine to relieve the symptoms occurred in climacteric disturbance. Since Japanese physicians frequently prescribe these formulas combined with etizolam, one of benzodiazepine anxiolytics, we evaluated the
[Practical analysis of toxic substances useful for clinical toxicology--10--benzodiazepine].
Yasushi Hori et al.
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 17(2), 163-168 (2004-07-23)
Yutaka Hirashima et al.
Neurologia medico-chirurgica, 45(12), 621-626 (2005-12-27)
Inflammatory reaction is very important for formation of the neomembrane of chronic subdural hematoma (CSDH). The present study evaluated medical treatment with the platelet-activating factor receptor antagonist, etizolam, for the resolution of CSDH, and the factors indicating surgery or conservative
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