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LM4114

Avanti

27-hydroxycholesterol (D6)

Avanti Research™ - A Croda Brand

Synonyme(s) :

cholest-5-ene-3β,27-diol(d6)

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About This Item

Formule empirique (notation de Hill):
C27H40D6O2
Numéro CAS:
1246302-95-3
Poids moléculaire :
408.69
Code UNSPSC :
12352100
Nomenclature NACRES :
NA.25

Forme

methanol solution

Conditionnement

pkg of 1 × 1 mL (LM4114-1EA)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand

Concentration

~10 μg/mL (Refer to C of A for lot specific concentration. )

Application(s)

lipidomics
metabolomics

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC([2H])(C(O)([2H])[2H])C([2H])([2H])[2H]

Catégories apparentées

Description générale

27-hydroxycholesterol is an abundant oxysterol in circulation.

Application

27-hydroxycholesterol (D6) or cholest-5-ene-3β,27-diol(d6) has been used as an internal standard to measure the concentration of 27-hydroxycholesterol in the pre- and post-statin-treated serum samples by mass spectrometry.

Actions biochimiques/physiologiques

27-hydroxycholesterol is known to induce breast cancer cell proliferation and metastatic progression in experimental models. It might serve as a ligand for liver X receptors (LXR) and farnesoid X-activated receptors (FXRs). 27-hydroxycholesterol controls the action of hydrocymethylglutaryl-CoA reductase. It promotes cholesterol efflux from the vascular endothelium.

Conditionnement

2 mL Amber Glass Sealed Ampule (LM4114-1EA)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organes cibles

Eyes

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

49.5 °F - closed cup

Point d'éclair (°C)

9.7 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Jeffrey Molendijk et al.
Biomolecules, 10(5) (2020-05-21)
Esophageal adenocarcinoma (EAC) incidence has been rapidly increasing, potentially associated with the prevalence of the risk factors gastroesophageal reflux disease (GERD), obesity, high-fat diet (HFD), and the precursor condition Barrett's esophagus (BE). EAC development occurs over several years, with stepwise
Nitai C Hait et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 4293-4310 (2020-02-06)
Sphingosine kinase 2 (SphK2) is known to phosphorylate the nuclear sphingolipid metabolite to generate sphingosine-1-phosphate (S1P). Nuclear S1P is involved in epigenetic regulation of gene expression; however, the underlying mechanisms are not well understood. In this work, we have identified
Byoungjae Kong et al.
Nature communications, 10(1), 185-185 (2019-01-16)
Membrane-disrupting agents that selectively target virus versus host membranes could potentially inhibit a broad-spectrum of enveloped viruses, but currently such antivirals are lacking. Here, we develop a nanodisc incorporated with a decoy virus receptor that inhibits virus infection. Mechanistically, nanodiscs

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