880120C

18:0 PEG2000 PE

Avanti Polar Lipids 880120C

• Synonyme(s) : 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)
• Numéro CAS: 474922-77-5
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Forme: liquid
• Conditionnement: pkg of 1 × 2.5 mL (880120C-25mg); pkg of 1 × 20 mL (880120C-500mg); pkg of 2 × 4 mL (880120C-200mg)
• Fabricant/nom de marque: Avanti Polar Lipids 880120C
• Concentration: 10 mg/mL (880120C-25mg); 25 mg/mL (880120C-200mg); 25 mg/mL (880120C-500mg)
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: [H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+]

Description

Description générale

18:0 PEG2000 PE, also known as 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000], is a modified phospholipid containing a 2000-Da PEG moiety in the polar head.

Application

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium salt (DSPE-PEG1) has been used to conjugate PEG onto residual amine groups on the surfaces of the functionalized TaO nanoparticles. DSPE-PEG1 may be used as a surfactant for homeotropic anchoring of the mesogen molecules. It may also be used in preparation of Nano formulations.

Actions biochimiques/physiologiques

PEG-modified lipids are typically added to phospholipid vesicles used for drug delivery to facilitate the formation of sterically stabilized liposomes (SSL). These liposomes have low reticuloendothelial system (RES) uptake and they prolong the circulating plasma half-life of the drug. The plasma half-life of the drug can be tuned from several hours to days depending on the size of the PEG and fatty acids attached to the lipid anchor.

Conditionnement

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (880120C-500mg)

5 mL Clear Glass Sealed Ampule (880120C-200mg)

5 mL Clear Glass Sealed Ampule (880120C-25mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372 - H412
• Conseils de prudence: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Classification des risques: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Organes cibles: Central nervous system
• Code de la classe de stockage: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): does not flash
• Point d'éclair (°C): does not flash