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860470P

Avanti

1-deoxysphingosine

Avanti Research™ - A Croda Brand 860470P, powder

Synonyme(s) :

1-deoxysphingosine (m18:1)

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About This Item

Formule empirique (notation de Hill):
C18H37NO
Numéro CAS:
193222-34-3
Poids moléculaire :
283.49
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Forme

powder

Conditionnement

pkg of 1 × 1 mg (860470P-1mg)
pkg of 1 × 10 mg (860470P-10mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 860470P

Type de lipide

bioactive lipids
sphingolipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

C[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC

Description générale

1-deoxysphingosine (1-deoxySO) has a (4E) double bond in its structure and is synthesized by the catabolism of 1-deoxyceramide in the presence of ceramidase enzyme. It is an unsaturated deoxy-sphingoid base.

Application

1-deoxysphingosine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing of MN9D dopaminergic neuroblastoma cell line and dorsal root ganglion neurons cultures. It may also be used as a standard for quantification of spingolipids from human plasma samples by liquid chromatography electrospray ionization tandem mass spectrometry (LC−ESI−MS/MS).

Actions biochimiques/physiologiques

1-deoxysphingosine levels are elevated in lymphoblasts in hereditary sensory neuropathy type 1 (HSAN1) disorder.

Conditionnement

5 mL Amber Glass Screw Cap Vial (860470P-10mg)
5 mL Amber Glass Screw Cap Vial (860470P-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

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Analysis of sphingolipids in extracted human plasma using liquid chromatography electrospray ionization tandem mass spectrometry
Bui HH, et al.
Analytical Biochemistry, 423(2), 187-194 (2012)
Regula Steiner et al.
Journal of lipid research, 57(7), 1194-1203 (2016-05-12)
The 1-deoxysphingolipids (1-deoxySLs) are formed by an alternate substrate usage of the enzyme, serine-palmitoyltransferase, and are devoid of the C1-OH-group present in canonical sphingolipids. Pathologically elevated 1-deoxySL levels are associated with the rare inherited neuropathy, HSAN1, and diabetes type 2
M F Dohrn et al.
European journal of neurology, 22(5), 806-814 (2015-01-28)
Diabetic distal sensorimotor polyneuropathy (DSPN) is a frequent, disabling complication of diabetes mellitus. There is increasing evidence that sphingolipids play a role in insulin resistance and type 2 diabetes (T2DM). Whether neurotoxic 1-deoxy-sphingolipids are elevated in DSPN patients' plasma and
Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids
Penno A, et al.
The Journal of Biological Chemistry, 285(15), 11178-11187 (2010)
Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
Martinez TN, et al.
Mol. Neurodegener., 7(1), 45-45 (2012)
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