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830865P

Avanti

18:0 PA

Avanti Research™ - A Croda Brand

Synonyme(s) :

1,2-dioctadecanoyl-sn-glycero-3-phosphate (sodium salt); DSPA; PA(18:0/18:0)

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About This Item

Formule empirique (notation de Hill):
C39H76O8PNa
Numéro CAS:
108321-18-2
Poids moléculaire :
726.98
Code UNSPSC :
51191904
Nomenclature NACRES :
NA.25

Description

1,2-distearoyl-sn-glycero-3-phosphate (sodium salt)

Pureté

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 25 mg (830865P-25mg)
pkg of 1 × 500 mg (830865P-500mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand

Type de lipide

cardiolipins
phospholipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

InChI

1S/C39H77O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h37H,3-36H2,1-2H3,(H2,42,43,44);/q;+1/p-1/t37-;/m1./s1

Clé InChI

ALPWRKFXEOAUDR-GKEJWYBXSA-M

Description générale

Phosphatidic acid (PA) has two fatty acids and one phosphate group attached to a glycerol backbone. The two fatty acids are present at position sn-1 and sn-2 of the C-atoms and the phosphate group is present in the sn-3 position of the C-atom.

Application

18:0 PA may be used:
  • as a component in the bilayer to study its vesiculation ability on different coat protein I (COPI) fission factor
  • to study its effects on intracellular Ca2+ concentration ([Ca2+]i) in C6 rat glioma and L2071 mouse fibroblast cells
  • to study its effects on phosphorylation of cytochrome b(558) alpha chain (p22phox)

Actions biochimiques/physiologiques

Phosphatidic acid (PA) acts as a biosynthetic precursor for the production of membrane glycerophospholipid and triacylglycerol. It participates in the modulation of mammalian target of rapamycin (mTOR) pathway. It may also participate in membrane trafficking, specifically in membrane fusion and fission.

Conditionnement

20 mL Clear Glass Screw Cap Vial (830865P-500mg)
5 mL Amber Glass Screw Cap Vial (830865P-25mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Souvent commandé avec ce produit

Réf. du produit
Description
Tarif

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Yang Liu et al.
Nature communications, 10(1), 5108-5108 (2019-11-11)
Mounting evidence suggests that the tumor microenvironment is profoundly immunosuppressive. Thus, mitigating tumor immunosuppression is crucial for inducing sustained antitumor immunity. Whereas previous studies involved intratumoral injection, we report here an inhalable nanoparticle-immunotherapy system targeting pulmonary antigen presenting cells (APCs)
Seung-Yeol Park et al.
Nature communications, 10(1), 3409-3409 (2019-08-01)
Studies on vesicle formation by the Coat Protein I (COPI) complex have contributed to a basic understanding of how vesicular transport is initiated. Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be required for the fission stage
Qiang Cheng et al.
Nature nanotechnology, 15(4), 313-320 (2020-04-07)
CRISPR-Cas gene editing and messenger RNA-based protein replacement therapy hold tremendous potential to effectively treat disease-causing mutations with diverse cellular origin. However, it is currently impossible to rationally design nanoparticles that selectively target specific tissues. Here, we report a strategy

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