700136P
Avanti
7α,27-dihydroxycholesterol-d6
Avanti Research™ - A Croda Brand 700136P, powder
Synonyme(s) :
7α,27-dihydroxycholesterol-d6
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About This Item
Formule empirique (notation de Hill):
C27H40D6O3
Numéro CAS:
Poids moléculaire :
424.69
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25
Produits recommandés
Pureté
>99% (TLC)
Forme
powder
Conditionnement
pkg of 1 × 1 mg (700136P-1mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand 700136P
Conditions d'expédition
dry ice
Température de stockage
−20°C
Description générale
7α,27-dihydroxycholesterol (7α,27-di-OHC) is synthesized by the hydroxylation of 27-hydroxycholesterol (27-OHC). It is an oxysterol with side chains oxidized and is a structural isomer of 7α,25-dihydroxycholesterol. 7α,27-dihydroxycholesterol-d6 is a deuterated derivative of 7α,27-di-OHC.
Application
7α,27-dihydroxycholesterol-d6 has been used as a deuterated internal standard in liquid chromatography electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS) for human plasma oxysterol analysis.
Actions biochimiques/physiologiques
7α,27-dihydroxycholesterol (7α,27-di-OHC) is a ligand for Epstein-Barr virus-induced gene 2 (EBI2). 7α27-di-OHC is implicated in neurological disease, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome and diabetes by lipidomics analysis of human cerebrospinal fluid (CSF) samples. The levels of 7α,27-di-OHC decreases in lipopolysaccharide activation.
Conditionnement
5 mL Amber Glass Screw Cap Vial (700136P-1mg)
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Souvent commandé avec ce produit
Réf. du produit
Description
Tarif
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Barbara Sottero et al.
Free radical biology & medicine, 144, 55-71 (2019-05-30)
High amounts of cholesterol have been definitely associated with the pathogenesis of several diseases, including metabolic and neurodegenerative disorders, cardiovascular diseases, and cancer. In all these pathologies the exacerbation of pro-oxidant and inflammatory responses is a consistent feature. In this
Valentin Mutemberezi et al.
Journal of neuroinflammation, 15(1), 74-74 (2018-03-11)
Oxysterols are cholesterol derivatives that have been suggested to play a role in inflammatory diseases such as obesity, atherosclerosis, or neuroinflammatory diseases. However, the effect of neuroinflammation on oxysterol levels has only been partially studied so far. We used an
Katharina R Beck et al.
Journal of lipid research, 60(9), 1535-1546 (2019-07-06)
Oxysterols previously were considered intermediates of bile acid and steroid hormone biosynthetic pathways. However, recent research has emphasized the roles of oxysterols in essential physiologic processes and in various diseases. Despite these discoveries, the metabolic pathways leading to the different
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