QBD10774

NHS-dPEG^®₂₄-biotin

• Synonyme(s) : Polyethylene glycol
• Formule empirique (notation de Hill): C₆₅H₁₂₀N₄O₃₀S
• Poids moléculaire : 1469.72
• Code UNSPSC : 51171641
• ID de substance PubChem : 329823948
• Nomenclature NACRES : NA.22

Propriétés

• Pureté: >90%
• Forme: solid or viscous liquid
• Capacité de réaction: reaction type: Biotinylations; reactivity: amine reactive
• Pertinence de la réaction: reagent type: cross-linking reagent
• Architecture des polymères: shape: linear; functionality: monofunctional
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: O=C(CCCCC1SCC(N2)C1NC2=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O

Description

Description générale

NHS-dPEG^®₂₄-biotin is a cross-linking reagent used in biotinylation reactions. The N-hydroxysuccinimidyl (NHS) moiety of NHS-dPEG^®₂₄-biotin forms a stable amide bond with free primary amines, such as the amines on the side chain of lysine. The biotin moiety is used in a variety of applications, including labeling, supramolecular building, affinity chromatography, pull-down assays, and the production of biotinylated antibodies.

Caractéristiques et avantages

NHS-dPEG^®₂₄-biotin is used extensively to label molecules that contain a free amine with biotin. The single molecular weight NHS-dPEG^®₂₄-biotin compound has a long spacer of precise length (97.7 Å) between the biotin moiety and the labeled molecule. This dPEG^® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG^® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

Informations légales

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable