936626

Fmoc-Val-Cit-PAB-PNP

≥95%

• Synonyme(s) : N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N⁵-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-L-ornithinamide (ACI), L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N⁵-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- (9CI, ACI)
• Formule empirique (notation de Hill): C₄₀H₄₂N₆O₁₀
• Numéro CAS: 863971-53-3
• Poids moléculaire : 766.80
• Numéro MDL: MFCD22200278
• Code UNSPSC : 12352209

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: powder or crystals
• Couleur: Off White to Yellow to Beige
• Température de stockage: 2-8°C
• Chaîne SMILES: C(OC(N[C@H](C(N[C@H](C(NC1=CC=C(COC(OC2=CC=C(N(=O)=O)C=C2)=O)C=C1 )=O)CCCNC(N)=0)=O)C(C)C)=O)C3C=4C(C=5C3-CC-CC5)=CC-CC4
• InChI: 1S/C40H42N6O10/c1-24(2)35(45-39(50)54-23-33-31-10-5-3-8-29(31)30-9-4-6-11-32(30)33)37(48)44-34(12-7-21-42-38(41)49)36(47)43-26-15-13-25(14-16-26)22-55-40(51)56-28-19-17-27(18-20-28)46(52)53/h3-6,8-11,13-20,24,33-35H,7,12,21-23H2,1-2H3,(H,43,47)(H,44,48)(H,45,50)(H3,41,42,49)/t34-,35-/m0/s1
• Clé InChI: USMYACISHVPTHK-PXLJZGITSA-N

Description

Application

This is a cathepsin cleavable linker used in bioconjugation, specifically in the construction of antibody drug conjugates (ADC & Bioconjugation).

Caractéristiques et avantages

Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B. Fmoc-Val-Cit-PAB-PNP has superior plasma stability comparable to that of non-cleavable linkers.

Autres remarques

ADC & Bioconjugation.

Chemical Biology Tools.

http://pubs.rsc.org/en/Content/ArticleLanding/2011/MB/C0MB00074D#!divAbstract