934232

Pomalidomide-2,6-diazaspiro[3.3]heptane

≥95.0%

• Synonyme(s) : 1H-Isoindole-1,3(2H)-dione, 5-(2,6-diazaspiro[3.3]hept-2-yl)-2-(2,6-dioxo-3-piperidinyl), 5-(2,6-Diazaspiro[3.3]heptan-2-yl)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
• Formule empirique (notation de Hill): C₁₈H₁₈N₄O₄
• Numéro CAS: 2226301-50-2
• Poids moléculaire : 354.36
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.21

Propriétés

• ligand: pomalidomide
• Niveau de qualité: 100
• Pureté: ≥95.0%
• Forme: powder or crystals
• Couleur: off-white to light yellow
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1N(C2CCC(NC2=O)=O)C(C3=CC=C(N4CC5(CNC5)C4)C=C31)=O

Description

Application

Pomalidomide-2,6-diazaspiro[3.3]heptane Hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Autres remarques

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informations légales

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H360D
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable