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932620

Sigma-Aldrich

NanoFabTx™ - Azide Lipid Mix

for synthesis of azide-functionalized liposomes

Synonyme(s) :

Azide-PEG-DSPE, Cholesterol, HSPC, PEG-PE

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About This Item

Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Niveau de qualité

100

Température de stockage

−20°C

Application

The NanoFabTx™ Azide Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of azide-functionalized liposomes, which can be used for targeting and immunotherapy applications, and small molecule encapsulation.

This product is a curated lyophilized lipid mixture of rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis azide-functionalized liposomes by extrusion and microfluidics are included. The synthesized azide-functionalized liposomes enables the conjugation of DBCO or alkyne-modified antibodies, proteins, aptamers, or other molecules to the liposomes surface which can be used for multi-targeting or multi-type cargo delivery to difference cell types including immune cells.

Caractéristiques et avantages

  • A ready-to-use nanoformulation lipid blend to synthesize azide-functionalized liposomes
  • Step-by-step protocols developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Optimized to make liposomes around 100 nm with low polydispersity
  • Optimized lipid blend for DBCO-modified protein or antibody conjugation
  • Optimized lipid blend for azide-functionalized liposomes for small molecule encapsulation
For microfluidic liposome synthesis of azide-functionalized liposomes, the NanoFabTx™- Azide Lipid Mix can be used with the the NanoFabTx™ Microfluidic - nano device kit (Cat.No. 911593). The NanoFabTx™ Microfluidic - nano device kit includes the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Informations légales

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

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Li Shen et al.
ACS omega, 5(23), 14111-14115 (2020-06-23)
Two Ac4ManNAz (AAM) derivatives with octadecanoic ester (C18 ester) and octadecyl ether (C18 ether) attached to the anomeric hydroxyl groups were synthesized and used in preparation of liposomes. Both liposomes show strong cell-labeling efficiencies on MDA-MB-231 cancer cells. The cell
Daxing Liu et al.
Nature communications, 9(1), 2612-2612 (2018-07-06)
The C-X-C chemokine receptor type 4 (CXCR4, CD184) pathway is a key regulator of cancer metastasis. Existing therapeutics that block CXCR4 signaling are dependent on single molecule-receptor interactions or silencing CXCR4 expression. CXCR4 localizes in lipid rafts and forms dimers

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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