930423

CP-alkyne

≥95%

• Synonyme(s) : 2,4,6-Trimethyl-1-(methyl((pent-4-yn-1-yloxy)carbonyl)amino)pyridin-1-ium tetrafluoroborate
• Formule empirique (notation de Hill): C₁₅H₂₁BF₄N₂O₂
• Poids moléculaire : 348.14
• Code UNSPSC : 41116164
• Nomenclature NACRES : NA.22

Propriétés

• Description: Application: Chemoproteomics
• Niveau de qualité: 100
• Essai: ≥95%
• Forme: liquid
• Température de stockage: −20°C
• Chaîne SMILES: CC1=CC(C)=[N+](N(C(OCCCC#C)=O)C)C(C)=C1.F[B-](F)(F)F
• Clé InChI: JEYOQLIMTNLUGZ-UHFFFAOYSA-N

Description

Application

CP-alkyne is a probe that can be used to photochemically label tryptophans. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications (Zanon et al. 2021). The method uses light or heavy labelling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016)

Autres remarques

1. Profiling the proteome-wide selectivity of diverse electrophiles

2. A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes

3. Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells

4. A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs

5. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile

6. Reversibility of Covalent Electrophile-Protein Adducts and Chemical Toxicity

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable