930083

2-(Pyrimidin-5-yl)phenol

≥95%

• Synonyme(s) : Maiti-Bag-Dutta Auxiliary
• Formule empirique (notation de Hill): C₁₀H₈N₂O
• Numéro CAS: 18313-50-3
• Poids moléculaire : 172.18
• Numéro MDL: MFCD06802618
• Code UNSPSC : 12352100
• Nomenclature NACRES : NA.21

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: powder
• Pf: 173 °C
• Température de stockage: −20°C

Description

Application

2-(Pyrimidin-5-yl)phenol is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-Fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.

2-(Pyrimidin-5-yl)phenol is an effective TDG for meta directed C-H functionalization of substitutes with a variety of electron withdrawing functional groups, with high selectivity.

Autres remarques

Arene diversification through distal C(sp2)−H functionalization
Palladium-Catalyzed meta-C–H Allylation of Arenes: A Unique Combination of a Pyrimidine-Based Template and Hexafluoroisopropanol

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable