907251

H-L-Photo-lysine HCl

≥98%

• Synonyme(s) : (S)-2-Amino-6-((2-(3-methyl-3H-diazirin-3-yl)ethoxy)carbonylamino)hexanoic acid hydrochloride, (S)-2-Amino-6-((2-(3H-diazirin-3-yl)propoxy)carbonylamino)hexanoic acid hydrochloride, 3′-Azibutyl-N-carbamoyl-lysine hydrochloride, Abk, Diazirine amino acid, Photo-Lys, Photo-crosslinking amino acid, Photoprobe building block
• Formule empirique (notation de Hill): C₁₁H₂₁ClN₄O₄
• Numéro CAS: 1253643-88-7
• Poids moléculaire : 308.76
• Numéro MDL: MFCD28133397
• Code UNSPSC : 12352209

Propriétés

• Essai: ≥98%
• Forme: powder
• Capacité de réaction: reaction type: solution phase peptide synthesis
• Disponibilité: available only in USA
• Application(s): peptide synthesis
• Température de stockage: −20°C
• Chaîne SMILES: N[C@@H](CCCCNC(=O)OCCC1(N=N1)C)C(=O)O
• InChI: 1S/C11H20N4O4/c1-11(14-15-11)5-7-19-10(18)13-6-3-2-4-8(12)9(16)17/h8H,2-7,12H2,1H3,(H,13,18)(H,16,17)/t8-/m0/s1
• Clé InChI: LUCMNTLJAFTFDU-QMMMGPOBSA-N

Description

Application

H-L-Photo-lysine HCl is a diazirine-containing lysine amino acid and multifunctional probe building blocks. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (~360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907383.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Autres remarques

A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation

Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking</A

Genetic code expansion for multiprotein complex engineering

Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells

Probing Protein-Protein Interactions with a Genetically Encoded Photo-crosslinking Amino Acid

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Informations sur la sécurité

• Pictogrammes: GHS02
• Mention d'avertissement: Danger
• Mentions de danger: H242
• Conseils de prudence: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Classification des risques: Self-react. C
• Code de la classe de stockage: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable