Accéder au contenu
MilliporeSigma
Toutes les photos(3)

Documents

777374

Sigma-Aldrich

DBCO-Cy5

for Copper-free Click Chemistry

Synonyme(s) :

ADIBO-Cy5, Azadibenzocyclooctyne-Cy5, Dibenzocyclooctyne-Cy5

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(3)

About This Item

Formule empirique (notation de Hill):
C64H86N6O11S3
Poids moléculaire :
1211.60
Code UNSPSC :
12171501
ID de substance PubChem :
329767903
Nomenclature NACRES :
NA.22

Niveau de qualité

100

Forme

solid

Capacité de réaction

reaction type: click chemistry

Température de stockage

−20°C

Chaîne SMILES 

CC[NH+](CC)CC.O=C(CCNC(CCCCC[N+]1=C(/C=C/C=C/C=C2C(C)(C)C3=CC(S([O-])(=O)=O)=CC=C3N\2CCCS([O-])(=O)=O)C(C)(C)C4=C1C=CC(S([O-])(=O)=O)=C4)=O)N5CC6=C(C=CC=C6)C#CC7=C5C=CC=C7.CC[NH+](CC)CC

InChI

1S/C52H56N4O11S3.2C6H15N/c1-51(2)42-34-40(69(62,63)64)25-27-45(42)54(31-14-6-9-22-49(57)53-30-29-50(58)56-36-39-18-11-10-16-37(39)23-24-38-17-12-13-19-44(38)56)47(51)20-7-5-8-21-48-52(3,4)43-35-41(70(65,66)67)26-28-46(43)55(48)32-15-33-68(59,60)61;2*1-4-7(5-2)6-3/h5,7-8,10-13,16-21,25-28,34-35H,6,9,14-15,22,29-33,36H2,1-4H3,(H3-,53,57,59,60,61,62,63,64,65,66,67);2*4-6H2,1-3H3

Clé InChI

PNVUJAWSQCGWCT-UHFFFAOYSA-N

Application

This azadibenzocyclooctyne-cyanine dye derivative is a versatile labeling reagent for detection of azide containing molecules or compounds. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions.This dibenzocyclooctyne will react with azide-functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Solubility : DMSO, DMF
Abs/Em - 646/661 nm
Extinction Coefficient:- 251,000 cm-1M-1
This azadibenzocyclooctyne-cyanine dye derivative is a versatile labeling reagent for detection of azide containing molecules or compounds. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions.This dibenzocyclooctyne will react with azide-functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Solubility : DMSO, DMF
Abs/Em - 646/661 nm
Extinction Coefficient:- 251,000 cm-1M-1

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Jianan Qiao et al.
Theranostics, 10(12), 5305-5321 (2020-05-07)
Chemo-photothermal synergistic treatment has a high potential to complement traditional cancer therapy and amplify its outcome. Precision in the delivery of these therapeutic agents to tumor cells has been indicated as being key to maximizing their therapeutic effects. Method: We
Edward S X Moh et al.
Analytical biochemistry, 584, 113385-113385 (2019-08-06)
Immunoglobulin M (IgM) type antibodies play a significant role in complement activation, cellular debris clearance and cell quality control, and have the potential to be used as a therapeutic or targeting/delivery antibody. However, this potential has not been explored thoroughly
Kirandeep K Deol et al.
Molecular cell, 80(5), 796-809 (2020-11-07)
The linkage, length, and architecture of ubiquitin (Ub) chains are all important variables in providing tight control over many biological paradigms. There are clear roles for branched architectures in regulating proteasome-mediated degradation, but the proteins that selectively recognize and process
Michael R Wasserman et al.
Cell, 178(3), 600-611 (2019-07-28)
The eukaryotic replicative helicase CMG is a closed ring around double-stranded (ds)DNA at origins yet must transition to single-stranded (ss)DNA for helicase action. CMG must also handle repair intermediates, such as reversed forks that lack ssDNA. Here, using correlative single-molecule
Anne Burgert et al.
Histochemistry and cell biology, 144(2), 123-131 (2015-07-04)
Single-molecule localization microscopy provides subdiffraction resolution images with virtually molecular resolution. Through the availability of commercial instruments and open-source reconstruction software, achieving super resolution is now public domain. However, despite its conceptual simplicity, localization microscopy remains prone to user errors.

Articles

Copper-Free Click Chemistry

Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique