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Key Documents

Autres documents

710806

Sigma-Aldrich

18-Hydroxycorticosterone

97% (CP)

Synonyme(s) :

4-Pregnene-11β,18,21-triol-3,20-dione

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About This Item

Formule empirique (notation de Hill):
C21H30O5
Numéro CAS:
561-65-9
Poids moléculaire :
362.46
Numéro Beilstein :
2631066
Numéro CE :
209-221-9
Numéro MDL:
MFCD00042685
Code UNSPSC :
12352211
ID de substance PubChem :
329763011
Nomenclature NACRES :
NA.24

Niveau de qualité

200

Pureté

97% (CP)

Forme

powder

Technique(s)

mass spectrometry (MS): suitable

Température de stockage

−20°C

Chaîne SMILES 

O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(CO)[C@@]3([H])CC[C@]4([H])C(CO)=O)=C1

InChI

1S/C21H30O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,14-17,19,22-23,25H,2-7,9-11H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

Clé InChI

HFSXHZZDNDGLQN-ZVIOFETBSA-N

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Catégories apparentées

Conditionnement

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
To best serve customer requests, each order is packaged and shipped on demand approximately 2 weeks after receipt of an order. If you have questions regarding availability and price, please contact the Stable Isotope Customer Service Group at 937-859-1808 (1-800-448-9760 for US & Canada) or email us at isosales@sial.com.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Paolo Mulatero et al.
The Journal of clinical endocrinology and metabolism, 97(3), 881-889 (2012-01-13)
Diagnosis of primary aldosteronism (PA) is made by screening, confirmation testing, and subtype diagnosis (computed tomography scan and adrenal vein sampling). However, some tests are costly and unavailable in most hospitals. The aim of the study was to evaluate the
P Vecsei et al.
Journal of steroid biochemistry, 19(1A), 345-351 (1983-07-01)
The value of the urine tests: free aldosterone, aldosterone-18-glucuronide, tetrahydroaldosterone 18-hydroxycorticosterone and 18-hydroxydeoxycorticosterone in distinguishing primary aldosteronism from essential hypertension was studied in patients with typical and atypical primary aldosteronism and in patients with essential hypertension. The discriminating function of
N Sonino et al.
Clinical endocrinology, 14(1), 31-39 (1981-01-01)
The effect of 24-h metyrapone administration on adrenal mineralocorticoid and glucocorticoid pathways has been studied in normal children. Urine and serum steroid concentrations were evaluated. Simultaneous determinations of deoxycorticosterone (DOC), corticosterone (B), cortisol (F), and aldosterone (aldo), in both urine
Richard J Auchus et al.
The Journal of clinical endocrinology and metabolism, 92(7), 2648-2651 (2007-05-03)
In primary aldosteronism, elevated serum 18-hydroxycorticosterone (18OHB) suggests aldosterone-producing adenoma (APA) rather than bilateral, idiopathic hyperaldosteronism (IHA), but little is known about the relative production of 18OHB and aldosterone (A) in APAs compared with IHA. We measured 18OHB, A, and
M Peter et al.
The Journal of clinical endocrinology and metabolism, 80(5), 1622-1627 (1995-05-01)
Aldosterone (Aldo), the most potent mineralocorticoid, is synthesized in the adrenal zona glomerulosa, requiring 11 beta-hydroxylation of 11-deoxycorticosterone (DOC) to form corticosterone (B), hydroxylation at position C18 to form 18-hydroxycorticosterone (18-OHB), and finally oxidation at position C18. There is a
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