215430

α-(4-Pyridyl N-oxide)-N-tert-butylnitrone

99%

• Synonyme(s) : N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide, N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide, POBN
• Formule empirique (notation de Hill): C₁₀H₁₄N₂O₂
• Numéro CAS: 66893-81-0
• Poids moléculaire : 194.23
• Numéro Beilstein : 1453764
• Numéro CE : 266-512-3
• Numéro MDL: MFCD00041022
• Code UNSPSC : 12352100
• ID de substance PubChem : 24852894
• Nomenclature NACRES : NA.22

Propriétés

• Pureté: 99%
• Forme: solid
• Pf: 183-185 °C (lit.)
• Solubilité: water: soluble 10 mg/mL, clear, colorless to faintly yellow
• Groupe fonctionnel: amine
• Chaîne SMILES: CC(C)(C)\[N+]([O-])=C/c1cc[n+]([O-])cc1
• InChI: 1S/C10H14N2O2/c1-10(2,3)12(14)8-9-4-6-11(13)7-5-9/h4-8H,1-3H3/b12-8+
• Clé InChI: RNRMWTCECDHNQU-XYOKQWHBSA-N

Description

Application

α-(4-Pyridyl N-oxide)-N-tert-butylnitrone was used as spin trapping agent to detect:

• the formation of hydroxyl radical adducts during decomposition of hydrogen peroxide in the presence of nickel (II) oligopeptides
• hydroxyl radicals and selenide radical anions

Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)