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Sigma-Aldrich

Oxonic acid potassium salt

97%

Synonyme(s) :

4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt, Allantoxanic acid

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About This Item

Formule empirique (notation de Hill):
C4H2KN3O4
Numéro CAS:
2207-75-2
Poids moléculaire :
195.17
Numéro CE :
218-627-5
Numéro MDL:
MFCD00010565
Code UNSPSC :
12352100
ID de substance PubChem :
24849591
Nomenclature NACRES :
NA.22

Pureté

97%

Pf

300 °C (lit.)

Chaîne SMILES 

[K+].[O-]C(=O)C1=NC(=O)NC(=O)N1

InChI

1S/C4H3N3O4.K/c8-2(9)1-5-3(10)7-4(11)6-1;/h(H,8,9)(H2,5,6,7,10,11);/q;+1/p-1

Clé InChI

IAPCTXZQXAVYNG-UHFFFAOYSA-M

Application

Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Jieyu Zuo et al.
The Journal of pharmacy and pharmacology, 70(1), 124-132 (2017-10-24)
Traditional Chinese herbal formulas are difficult to be understood because of complex compositions and specific therapeutic principles. To better understand herbal compatibility in Traditional Chinese medicine (TCM), this study was conducted to investigate the effects of a Chinese pharmacopoeia-listed formula
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PloS one, 14(4), e0214862-e0214862 (2019-04-06)
The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first established a rat model of hyperuricemia without marked symptoms of chronic kidney failure by 10-day co-administration of
T Shirasaka et al.
Cancer research, 53(17), 4004-4009 (1993-09-01)
The possibility of decreasing the gastrointestinal (GI) toxic effects of 5-fluorouracil (5-FU) on the digestive tract such as its injury of cells and induction of diarrhea, without reducing its antitumor activity, was investigated in rats. Oxonic acid was found to
Yasushi Habu et al.
Biochemical pharmacology, 69(6), 993-999 (2005-03-08)
We previously reported that in hyperuricemic rats, renal impairment occurred and organic ion transport activity decreased, accompanied with a specific decrease in the expression of rat organic anion transporters, rOAT1 and rOAT3, and organic cation transporter, rOCT2. In the present
Shinichi Honda et al.
Bioscience, biotechnology, and biochemistry, 78(4), 655-661 (2014-07-19)
We applied Chrysanthemum flower oil (CFO) to a hyperuricemia model by feeding rats a hyperuricemia-inducing diet (HID) and investigated its effect on serum uric acid (SUA) levels and its mode of action. CFO is the oily fraction that contains polyphenols
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