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Merck

NQO1

NAD(P)H dehydrogenase, quinone 1

Synonymes:
DHQU, DIA4, DTD, NMOR1, NMORI, QR1
Espèce(s):
Human NQO1 (1728), Mouse Nqo1 (18104), Rat Nqo1 (24314), sheep NQO1 (101121876), naked mole-rat Nqo1 (101711262), domestic guinea pig Nqo1 (100135582), Zebrafish nqo1 (322506), dog NQO1 (610935), domestic cat NQO1 (101097859), cow NQO1 (519632)
ID UniProtKB:
P15559, B2R5Y9, B4DNM7, B7ZAD1, Q86UK1
ID du gène:
  • Human(1728) Summary: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Mouse(18104) NAD(P)H dehydrogenase, quinone 1
  • Rat(24314) NAD(P)H dehydrogenase, quinone 1
  • sheep(101121876) NAD(P)H dehydrogenase, quinone 1
  • naked mole-rat(101711262) NAD(P)H dehydrogenase, quinone 1
  • domestic guinea pig(100135582) NAD(P)H dehydrogenase, quinone 1
  • Zebrafish(322506) NAD(P)H dehydrogenase, quinone 1
  • dog(610935) NAD(P)H dehydrogenase, quinone 1
  • domestic cat(101097859) NAD(P)H dehydrogenase, quinone 1
  • cow(519632) NAD(P)H dehydrogenase, quinone 1
  • chicken(769737) NAD(P)H dehydrogenase, quinone 1

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ELISA

Product Number
Description
Espèce(s)
RAB1605
Human NQO-1 ELISA, for serum, plasma and cell culture supernatants,
Espèce(s)
human

Antibodies

Product Number
Description
Espèces réactives
Application
HPA007308
Anti-NQO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
ZRB1707
Anti-NQO1 Antibody, clone 1D12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
western blot
SAB1410299
Anti-NQO1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human, mouse
Application
western blot
SAB5701284
Anti-NQO1 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
SAB5300232
Monoclonal Anti-NQO1 antibody produced in mouse, clone 4D12, ascites fluid,
Espèces réactives
human
Application
ELISA
flow cytometry
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Espèce(s)
M5625
Menadione, crystalline,
Espèce(s)
human
M9429
Menadione, meets USP testing specifications,
Espèce(s)
human
47775
Menadione (K3), analytical standard,
Espèce(s)
human

Proteins

Product Number
Description
Espèce(s)
D1315
DT Diaphorase (NQO1) human, lyophilized powder, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Espèce(s)
human
SRP6539
NQO1 human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE),
Espèce(s)
human

esiRNA

Product Number
Description
Espèce(s)
EMU088081
MISSION® esiRNA, targeting mouse Nqo1,
Espèce(s)
mouse
EHU047441
MISSION® esiRNA, targeting human NQO1,
Espèce(s)
human