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Merck

MMP14

matrix metallopeptidase 14 (membrane-inserted)

Synonymes:
MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1
Espèce(s):
Human MMP14 (4323), Mouse Mmp14 (17387), Rat Mmp14 (81707), chicken MMP14 (426253), cow MMP14 (281915), Horse MMP14 (100034170), domestic cat MMP14 (101089776), dog MMP14 (403823), naked mole-rat Mmp14 (101723795), Domestic Rabbit MMP14 (100009598) ...Plus
ID UniProtKB:
P50281, A8K5L0, Q6GSF3, Q92678
ID du gène:
  • Human(4323) Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
  • Mouse(17387) matrix metallopeptidase 14 (membrane-inserted)
  • Rat(81707) matrix metallopeptidase 14 (membrane-inserted)
  • chicken(426253) matrix metallopeptidase 14 (membrane-inserted)
  • cow(281915) matrix metallopeptidase 14 (membrane-inserted)
  • Horse(100034170) matrix metallopeptidase 14 (membrane-inserted)
  • domestic cat(101089776) matrix metallopeptidase 14 (membrane-inserted)
  • dog(403823) matrix metallopeptidase 14 (membrane-inserted)
  • naked mole-rat(101723795) matrix metallopeptidase 14 (membrane-inserted)
  • Domestic Rabbit(100009598) matrix metallopeptidase 14 (membrane-inserted)
  • domestic guinea pig(100732039) matrix metallopeptidase 14 (membrane-inserted)
  • sheep(443116) matrix metallopeptidase 14 (membrane-inserted)

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Antibodies

Product Number
Description
Espèces réactives
Application
MAB3328
Anticorps anti-MMP-14, domaine catalytique, clone LEM-2/15.8, clone LEM-2/15.8, Chemicon®, from mouse,
Espèces réactives
human, mouse
Application
ELISA
immunoprecipitation (IP)
western blot
AB8345
Anti-MMP-14 Antibody, serum, Chemicon®,
Espèces réactives
human
Application
ELISA
flow cytometry
immunocytochemistry
immunoprecipitation (IP)
western blot
MAB1767
Anticorps anti-domaine catalytique de la MT1-MMP humaine, clone 3G4.2, clone 3G4.2, Chemicon®, from mouse,
Espèces réactives
human
Application
immunocytochemistry
immunohistochemistry
western blot
AB6004
Anti-MT1-MMP Antibody, hinge region, from rabbit, purified by affinity chromatography,
Espèces réactives
human, rat
Application
immunohistochemistry
western blot
SAB4501901
Anti-MMP-14 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Espèce(s)
M2699
Marimastat, ≥98% (HPLC),
Espèce(s)
human, rat, mouse
P0047
PD166793 hydrate, ≥98% (HPLC),
Espèce(s)
human, rat, mouse

Proteins

Product Number
Description
Espèce(s)
CC1043
MMP-14, human, prodomain, catalytic domain, and hemopexin domain, E. coli recombinant, ,
Espèce(s)
human

esiRNA

Product Number
Description
Espèce(s)
EHU152001
MISSION® esiRNA, targeting human MMP14,
Espèce(s)
human
EMU050191
MISSION® esiRNA, targeting mouse Mmp14,
Espèce(s)
mouse