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CHRNA4

cholinergic receptor, nicotinic, alpha 4 (neuronal)

Synonymes:
BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(1137) Summary: This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
  • Mouse(11438) cholinergic receptor, nicotinic, alpha polypeptide 4
  • Rat(25590) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • sheep(101118889) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • Domestic Rabbit(100345481) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • domestic guinea pig(100716877) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • naked mole-rat(101714448) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • Zebrafish(556619) cholinergic receptor, nicotinic, alpha 4
  • domestic cat(101101300) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • cow(537251) cholinergic receptor, nicotinic, alpha 4
  • Horse(100146784) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • dog(485972) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • chicken(395606) cholinergic receptor, nicotinic, alpha 4

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Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
(−)-nicotine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
(−)-Nicotine hemisulfate salt, ≥95% (TLC), ~35 % (w/v) in H2O (based on free base),
Espèce(s)
human
(−)-Nicotine, PESTANAL®, analytical standard,
Espèce(s)
human
(±)-Nicotine, ≥99% (TLC), liquid,
Espèce(s)
human, rat
Carbamoylcholine chloride, ≥98% (titration), crystalline,
Espèce(s)
human, mouse, rat

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
Myosmine, ≥98%,
Espèce(s)
rat
(±)-Nornicotine, ≥98% (TLC), liquid,
Espèce(s)
mouse, rat
Cytisine, ≥99%, powder,
Espèce(s)
rat
(±)-Nicotine, ≥99% (TLC), liquid,
Espèce(s)
human, rat
Carbamoylcholine chloride, ≥98% (titration), crystalline,
Espèce(s)
human, mouse, rat

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-nAChR α4 Subunit Antibody, clone 369, clone 369, from mouse,
Espèces réactives
human, monkey, rabbit
Application
immunofluorescence
immunohistochemistry
Anti-Nicotinic Acetylcholine Receptor α4 Antibody, from rabbit, purified by affinity chromatography,
Espèces réactives
human, mouse, rat
Application
western blot
Anti-CHRNA4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot
Anti-ACHA4 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
Tetraethylammonium chloride, ≥98% (titration),
Espèce(s)
human
Hexamethonium bromide, ,
Espèce(s)
human
Hexamethonium chloride, solid (hygroscopic),
Espèce(s)
human
Acide kynurénique, ≥98%,
Espèce(s)
rat, human