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1078507

USP

Bupivacaine hydrochloride

Name: Bupivacaine hydrochloride
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Bupivacaine hydrochloride monohydrate, 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₈N₂O · HCl · H₂O

CAS Number:

73360-54-0

Molecular Weight:

342.90

UNSPSC Code:

41116107

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

bupivacaine

manufacturer/tradename

USP

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

Related Categories

Analytical Chromatography

Chromatography Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Bupivacaine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Bupivacaine Hydrochloride Injection
Bupivacaine Hydrochloride in Dextrose Injection
Bupivacaine Hydrochloride and Epinephrine Injection
Fentanyl Citrate and Bupivacaine Hydrochloride Compounded Injection
Ropivacaine Hydrochloride

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

Pictograms

GHS06

Signal Word

Danger

Hazard Statements

H300 + H310 + H330

Precautionary Statements

P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ropivacaine Related Compound A

Sigma-Aldrich

R0283

Ropivacaine hydrochloride monohydrate

Supelco

36766

2,6-Dimethylaniline

Sigma-Aldrich

L7757

Lidocaine

Bupivacaine Hydrochloride and Epinephrine Injection

United States Pharmacopeia and National Formulary

United States Pharmacopeia, 612-612 (2018)

Comparison of unilateral spinal anesthesia and L₁ paravertebral block combined with psoas compartment and sciatic nerve block in patients to undergo partial hip prosthesis.

I Demirel et al.

European review for medical and pharmacological sciences, 18(7), 1067-1072 (2014-04-26)

Just as hip prosthesis, most of the patients undergoing orthopedic lower extremity surgery (OLES) belong to the advanced age group. Sciatic nerve block combined with psoas compartment block is used as a technique alternative to central neuraxial block and GA.

The effect of transversus abdominis plane blocks on postoperative pain in laparoscopic colorectal surgery: a prospective, randomized, double-blind trial.

Deborah S Keller et al.

Diseases of the colon and rectum, 57(11), 1290-1297 (2014-10-07)

Superior early pain control has been suggested with transversus abdominis plane blocks, but evidence-based recommendations for transversus abdominis plane blocks and their effects on patient outcomes are lacking. The aim of this study was to determine whether transversus abdominis plane

The effect of intraarticular levobupivacaine and bupivacaine injection on the postoperative pain management in total knee artroplastic surgery.

Nurcan Yavuz et al.

Pakistan journal of medical sciences, 30(6), 1286-1292 (2015-02-13)

Total knee arthroplasty (TKA) is associated with considerable postoperative pain. We compared the effects of intraoperative intraarticular levobupivacaine and bupivacaine on postoperative analgesia and analgesic consumption after total knee arthroplasty. Sixty ASA (American Society of Anesthesiologists) physical status II-III, 18-75

Potential avoidance of adverse analgesic effects using a biologically "smart" hydrogel capable of controlled bupivacaine release.

Francesca Taraballi et al.

Journal of pharmaceutical sciences, 103(11), 3724-3732 (2014-10-01)

Acute pain remains a tremendous clinical and economic burden, as its prevalence and common narcotic-based treatments are associated with poorer outcomes and higher costs. Multimodal analgesia portends great therapeutic promise, but rarely allows opioid sparing, and new alternatives are necessary.

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