V9389
Violacein from Janthinobacterium lividum
>98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)
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About This Item
Empirical Formula (Hill Notation):
C20H13N3O3
CAS Number:
Molecular Weight:
343.34
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
>98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)
solubility
H2O: insoluble
acetone: soluble
ethanol: soluble
methanol: soluble
storage temp.
2-8°C
InChI
1S/C20H13N3O3/c24-10-5-6-15-12(7-10)14(9-21-15)17-8-13(19(25)23-17)18-11-3-1-2-4-16(11)22-20(18)26/h1-9,21,24H,(H,22,26)(H,23,25)/b18-13-
InChI key
XAPNKXIRQFHCHN-AQTBWJFISA-N
General description
Violacein from Janthinobacterium lividum is used as a colorant for natural and synthetic fabrics. It functions as a respiratory pigment and regulates tryptophan production. Violacein exhibits anti-protozoal activity.
Application
Violacein from Janthinobacterium lividum has been used:
- for cell culture assays
- as a standard to determine the crude violacein concentration in ethanol extracts of D. violaceinigra str. NI28 cultures
- as a standard to identify violacein in the leaf samples of Nicotiana
Biochem/physiol Actions
Violacein, a violet pigment, is an indole derivative produced by various bacterial strains such as Chromobacterium violaceum, Janthinobacterium lividum, Chromobacterium lividum, and Pseudoalteromonas luteoviolacea. Violacein is a member of a novel class of cytotoxic drugs, which mediate apoptosis. Violacein exhibits antitumoral, antibacterial, antiulcerogenic, antileishmanial, and antiviral activities. Violacein and its β-cyclodextrin complexes trigger apoptosis and differentiation in HL60 leukemic cells. Violacein cytotoxicity is preceded by activation of caspase 8, transcription of NF-κB target genes, and p38-MAPK activation resembling TNF-α signal transduction.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026
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The present work highlighted the production of violacein by the locally isolated Chromobacterium violaceum (GenBank accession no. HM132057) in various agricultural waste materials (sugarcane bagasse, solid pineapple waste, molasses, brown sugar), as an alternative to the conventional rich medium. The
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