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T7567

Sigma-Aldrich

Tributylphosphine solution

200 mM (in N-methyl-2-pyrrolidinone), liquid

Synonym(s):

TBP

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About This Item

Empirical Formula (Hill Notation):
C12H27P
CAS Number:
998-40-3
Molecular Weight:
202.32
MDL number:
MFCD00009462
UNSPSC Code:
41105323
PubChem Substance ID:
24900459
NACRES:
NA.56

form

liquid

Quality Level

100

concentration

200 mM (in N-methyl-2-pyrrolidinone)

SMILES string

CCCCP(CCCC)CCCC

InChI

1S/C12H27P/c1-4-7-10-13(11-8-5-2)12-9-6-3/h4-12H2,1-3H3

InChI key

TUQOTMZNTHZOKS-UHFFFAOYSA-N

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Application

TBP is an uncharged reducing agent for disulfide bonds of cysteine residues. This reagent is ideally suited for preparation of protein samples prior to IEF and 2D electrophoresis. Reduction with TBP and subsequent alkylation with iodoacetamide improves resolution, allows greater sample loads, and therefore, improves visualization of low abundance proteins

Packaging

Sealed ampule of 0.5 mL

Signal Word

Danger

Hazard Statements

H314,H335,H360D,H412

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Repr. 1B - Skin Corr. 1A - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

186.8 °F - closed cup

Flash Point(C)

86 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Stuart Thomson et al.
Clinical & experimental metastasis, 25(8), 843-854 (2008-08-13)
NSCLC cells with a mesenchymal phenotype have shown a marked reduction in sensitivity to EGFR inhibitors, though the molecular rationale has remained obscure. Here we find that in mesenchymal-like tumor cells both tyrosine phosphorylation of EGFR, ErbB2, and ErbB3 signaling
Tien Q Pham et al.
The Journal of organic chemistry, 70(16), 6369-6377 (2005-07-30)
The phosphine-catalyzed [3 + 2]-cycloaddition of 5-methylenehydantoins 4 with the ylides 5, derived from addition of tributylphosphine to the 2-butynoic acid derivatives, 6a-d, gives spiro-heterocyclic products. The camphor sultam derivative 6b gives optically active products. Noteable was that the ylides
T Oe et al.
Journal of chromatography. B, Biomedical sciences and applications, 708(1-2), 285-289 (1998-07-08)
A method was developed for the simultaneous determination of gamma-glutamylglutathione (gamma-GluGSH) and other low-molecular-mass thiol compounds (cysteine, cysteamine, homocysteine, cysteinylglycine, gamma-glutamylcysteine, glutathione and N-acetylcysteine) using high-performance liquid chromatography combined with precolumn fluorescence labeling with ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate (SBD-F). These SBD-labeled thiol
Kornelis S M van der Geest et al.
Rheumatology (Oxford, England), 54(5), 950-958 (2014-10-24)
The aim of this study was to investigate the turnover of Treg cells in the SF of RA patients. Treg cells were enumerated in peripheral blood and SF of RA patients and analysed by flow cytometry for expression of the
Toon Verheyen et al.
Nucleic acids research, 43(12), 5771-5784 (2015-05-21)
Protein phosphatase-1 (PP1) is a key regulator of transcription and is targeted to promoter regions via associated proteins. However, the chromatin binding sites of PP1 have never been studied in a systematic and genome-wide manner. Methylation-based DamID profiling in HeLa
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