SML2235
CL075
≥98% (HPLC)
Synonym(s):
2-Propylthiazolo[4,5-c]quinolin-4-amine, 3M002
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C13H13N3S
CAS Number:
Molecular Weight:
243.33
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
InChI
1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)
InChI key
NFYMGJSUKCDVJR-UHFFFAOYSA-N
Application
CL075 has been used to activate the monocyte-derived dendritic cells (DCs) to demonstrate the ability of DCs to induce cell death.
Biochem/physiol Actions
CL075 is a selective agonist of Toll-like receptor-8 (TLR-8) with immunostimulant activity. It showed an EC50 value of 400nM for IRF-NFΚB stimulation in TLR8 compared to 4 μM for TLR7.
CL075 is a thiazoloquinolone derivative. It might influence tumor development.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Cytotoxic activity of human dendritic cells induces RIPK1-dependent cell death
Varga Z, et al.
Immunobiology, 152032-152032 (2020)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service