SML1671

NCT-503 Inactive Control

≥98% (HPLC)

• Synonym(s): N-(4,6-Dimethylpyridin-2-yl)-4-(pyridin-4-yl)piperazine-1-carbothioamide
• Empirical Formula (Hill Notation): C₁₇H₂₁N₅S
• CAS Number: 1914971-16-6
• Molecular Weight: 327.45
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826006
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: CC1=CC(NC(N2CCN(C3=CC=NC=C3)CC2)=S)=NC(C)=C1
• InChI: 1S/C17H21N5S/c1-13-11-14(2)19-16(12-13)20-17(23)22-9-7-21(8-10-22)15-3-5-18-6-4-15/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,23)
• InChI key: ITLPIAAGIQAGRA-UHFFFAOYSA-N

Description

Application

NCT-503 Inactive Control has been used as a small molecule inhibitor of phosphoglycerate dehydrogenase in neuroblastoma cells.

Biochem/physiol Actions

NCT-503 Inactive Control is the inactive control probe for NCT-503, which is an inhibitor of phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first, rate-limiting step of glucose-derived serine synthesis. NCT-503 Inactive Control has an IC₅₀ value >57 μM for PHGDH. NCT-503 has an IC₅₀ value of 2.5 μM for PHGDH. NCT-503 Inactive Control is water soluble and has good stability, similar to NCT-503.

Recommended products

The active PHGDH inhibitor, NCT-503, is available from Sigma. To learn more about and purchase NCT-503, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315
• Precautionary Statements: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable