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SML0912

Sigma-Aldrich

SB 674042

≥98% (HPLC)

Synonym(s):

(2S)- 1-[[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-pyrrolidine (9CI), (S)-1-[5-[2-Fluorophenyl]-2-methylthiazol-4-yl]-1-[2-[[5-phenyl-[1,3,4]oxadiazol-2-yl]methyl]pyrrolidin-1-yl]methanone, SB-674042

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About This Item

Empirical Formula (Hill Notation):
C24H21FN4O2S
CAS Number:
483313-22-0
Molecular Weight:
448.51
UNSPSC Code:
51111800
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C24H21FN4O2S/c1-15-26-21(22(32-15)18-11-5-6-12-19(18)25)24(30)29-13-7-10-17(29)14-20-27-28-23(31-20)16-8-3-2-4-9-16/h2-6,8-9,11-12,17H,7,10,13-14H2,1H3/t17-/m0/s1

InChI key

HYBZWVLPALMACV-KRWDZBQOSA-N

Biochem/physiol Actions

SB-674042 is potent and selective OX1R antagonist. SB-674042 binds with high affinity to OX1R and mediates intracellular calcium flux in OX1R-expressing cells.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xiaocen Chang et al.
Pancreas, 48(4), 568-573 (2019-04-05)
The study aimed to investigate the involvement of the mammalian target of rapamycin (mTOR) signaling pathway in orexin-A/OX1 receptor-induced insulin secretion in rat insulinoma INS-1 cells. Rat insulinoma INS-1 cells were grown and treated with various concentrations of orexin-A, with

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