SML0664

LM11A-31 dihydrochloride

≥95% (HPLC)

• Synonym(s): 2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-pentanamide dihydrochloride
• Empirical Formula (Hill Notation): C₁₂H₂₅N₃O₂ · 2HCl
• CAS Number: 1214672-15-7
• Molecular Weight: 316.27
• MDL number: MFCD11505486
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825578
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: oil
• storage condition: desiccated
• color: colorless to yellow
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.CCC(C)C(N)C(=O)NCCN1CCOCC1
• InChI: 1S/C12H25N3O2.2ClH/c1-3-10(2)11(13)12(16)14-4-5-15-6-8-17-9-7-15;;/h10-11H,3-9,13H2,1-2H3,(H,14,16);2*1H
• InChI key: LLIHJRRZJDEKLB-UHFFFAOYSA-N

Description

Application

LM11A-31 dihydrochloride has been used to study the effect of p75 neurotrophin receptor (p75 NTR) blockade, by non-peptide LM11A-31 ligand, on PC12 cell viability.

Biochem/physiol Actions

LM11A-31 is a non-peptide ligand of the p75 neurotrophin receptor (p75NTR). LM11A-31 blocks pro-NGF induced cell death in neuronal cultures, and protects neuronal cells from the the cytotoxic effects of cisplatin or methotrexate. Oral administration of LM11A-31 promotes the survival of oligodendrocytes and myelinated axons in a mouse spinal cord injury model and improves function in both weight-bearing and non-weight bearing tests.

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H315,H319,H335,H410
• Precautionary Statements: P273 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable