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SML0466

Sigma-Aldrich

LCS-1

≥98% (HPLC)

Synonym(s):

4,5-Dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone

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About This Item

Empirical Formula (Hill Notation):
C11H8Cl2N2O
CAS Number:
41931-13-9
Molecular Weight:
255.10
MDL number:
MFCD00814448
UNSPSC Code:
12352200
PubChem Substance ID:
329824744

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solutikon, warmed)

storage temp.

2-8°C

SMILES string

O=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(C)=C2

InChI

1S/C11H8Cl2N2O/c1-7-3-2-4-8(5-7)15-11(16)10(13)9(12)6-14-15/h2-6H,1H3

InChI key

SYUPLLHVMCLXEM-UHFFFAOYSA-N

Biochem/physiol Actions

LCS-1 is an inhibitor of superoxide dismutase (SOD1). LCS-1 inhibits the proliferation of lung adendocarcinoma cell lines.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301 - H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Aditi Mishra et al.
Scientific reports, 8(1), 901-901 (2018-01-19)
Extrinsic control of single neurons and neuronal populations is a powerful approach for understanding how neural circuits function. Adding new thermogenetic tools to existing optogenetic and other forms of intervention will increase the complexity of questions that can be addressed.
Shuai Li et al.
Cell communication and signaling : CCS, 16(1), 28-28 (2018-06-13)
SOD1 is an abundant enzyme that has been studied as a regulator of the antioxidant defence system, and this enzyme is well known for catalyzing the dismutation of superoxide into hydrogen peroxide. However the SOD1 in the progress of NPC
Ting Du et al.
Leukemia, 35(2), 550-561 (2020-05-20)
Our prior study showed that inhibition of 19S proteasome-associated ubiquitin receptor Rpn13 can overcome bortezomib resistance in MM cells. Here, we performed proteomic analysis of Rpn13 inhibitor (RA190)-treated MM cells and identified an antioxidant enzyme superoxide dismutase (SOD1) as a
Young-Ok Son et al.
The Journal of biological chemistry, 289(41), 28660-28675 (2014-08-27)
The cadmium-transformed human lung bronchial epithelial BEAS-2B cells exhibit a property of apoptosis resistance as compared with normal non-transformed BEAS-2B cells. The level of basal reactive oxygen species (ROS) is extremely low in transformed cells in correlation with elevated expressions

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