SAB5700345

Anti-Phospho-STAT2-Y690 antibody produced in rabbit

• Synonym(s): IMD44, ISGF-3, P113, STAT113, STAT2
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 97
• species reactivity: rat, mouse, human
• concentration: 0.21 mg/ml
• technique(s): western blot: 1:500-1:1000
• UniProt accession no.: P52630
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr690)
• Gene Information: human ... STAT2(6773)

Description

General description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Immunogen

A synthetic phosphorylated peptide around Y690 of human STAT2 (NP_005410.1).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable