SAB4700594
Monoclonal Anti-CD90.2, azide free antibody produced in mouse
clone 1aG4/C5, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-Thy-1.2, Anti-Thy1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
1aG4/C5, monoclonal
form
buffered aqueous solution
species reactivity
mouse
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG3
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
mouse ... Thy1(21838)
General description
Cluster of differentiation 90.2 (CD90.2), also known as Thy-1.2, is a 25-37kDa GPI-anchored protein, encoded by the gene mapped to mouse chromosome 9. The protein is mainly localized on the external leaflet of the lipid bilayer and lipid rafts. The encoded protein is one of the allele of CD90 and is expressed primarily on murine T-cells.
The mouse monoclonal antibody 1aG4/C5 recognizes alloantigen Thy-1.2 of mouse Thy-1 (CD90); it does not cross-react with Thy-1.1 alloantigen. Thy-1 is an 18-35 kDa cell surface GPI linked glycoprotein (immunoglobulin superfamily); in mouse it is abundant on thymocytes and peripheral T lymphocytes.
Immunogen
thymocytes from C3H/Di mice (Thy-12 positive)
Application
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Biochem/physiol Actions
Cluster of differentiation 90.2 (CD90.2) plays a major role in T-cell activation. In addition, it is also implicated in various nonimmunologic functions such as, inhibition of neurite outgrowth, apoptotic signaling, leukocyte and melanoma cell adhesion and migration, tumor suppression and fibroblast proliferation and migration. CD90. also acts as a tumor suppressor in ovarian cancer and nasopharyngeal carcinoma (NPC). Deficiency of CD90 is associated with the development of pulmonary fibrosis. The protein expressed in choroidal endothelial cells (CECs) modulates VEGF-mediated CEC activation and migration.
Features and Benefits
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Physical form
Solution in azide free HEPES buffer, pH 7
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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John E Bradley et al.
BioFactors (Oxford, England), 35(3), 258-265 (2009-05-08)
Thy-1 or CD90 is a glycophosphatidylinositol-linked glycoprotein expressed on the surface of neurons, thymocytes, subsets of fibroblasts, endothelial cells, mesangial cells and some hematopoietic cells. Thy-1 is evolutionarily conserved, developmentally regulated, and often has dramatic effects on cell phenotype; however
Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis.
Rege TA and Hagood JS
Faseb Journal, 20, 1045-1054 (2006)
TGF-β1 epigenetically modifies Thy-1 expression in primary lung fibroblasts
Neveu WA
American Journal of Physiology. Cell Physiology, 309, C616-C626 (2015)
Thy-1 Regulates VEGF-Mediated Choroidal Endothelial Cell Activation and Migration: Implications in Neovascular Age-Related Macular Degeneration
Wang H
Investigative Ophthalmology & Visual Science, 57, 5525-5534 (2016)
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