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Key Documents

SAB4500005

Sigma-Aldrich

Anti-BCL-2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, BCL2

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About This Item

MDL number:
MFCD00239644
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 26 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P10415

UniProt accession no.

P10415

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BCL2(596)

General description

B-cell lymphoma 2 (BCL-2) is an anti-apoptotic and target gene of nuclear factor-κB (NF-κB). The protein is expressed in the nuclear envelope, mitochondria and endoplasmic reticulum. The gene encoding BCL-2 is localized on human chromosome 18q21. Anti-BCL-2 Antibody detects endogenous levels of total BCL-2 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human BCL-2.

Immunogen Range: 41-90

Biochem/physiol Actions

B-cell lymphoma 2 (BCL-2) inhibits apoptosis in cells and has been shown to be upregulated in adenomas.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P. Riederer
Advances in Research on Neurodegeneration null
P. Riederer
Advances in Research on Neurodegeneration, 5 null
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents.
Stornaiuolo M
Journal of Medicinal Chemistry, 58(5), 2135-2148 (2015)
Bryce Patrick Portier et al.
The Journal of biological chemistry, 281(52), 40493-40502 (2006-11-09)
Bcl-2 is the best characterized member of a large family of proteins that regulate apoptosis. Although it is established that Bcl-2 localized at the mitochondria functions as an anti-apoptotic protein, the function of Bcl-2 at the nucleus remains unclear. Recently
Maartje van der Heijden et al.
Nature communications, 7, 10916-10916 (2016-03-10)
Intestinal tumour formation is generally thought to occur following mutational events in the stem cell pool. However, active NF-κB signalling additionally facilitates malignant transformation of differentiated cells. We hypothesized that genes shared between NF-κB and intestinal stem cell (ISCs) signatures

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