SAB4300222

Anti-phospho-EIF2AK2 (pThr⁴⁴⁶) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-EIF2AK1 antibody produced in rabbit, Anti-MGC126524 antibody produced in rabbit, Anti-PKR antibody produced in rabbit, Anti-PRKR antibody produced in rabbit, Anti-eukaryotic translation initiation factor 2-alpha kinase 2 antibody produced in rabbit
• MDL number: MFCD03455796
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~74 kDa
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (K-R-TP-R-S)
• NCBI accession no.: NP_001129123.1
• UniProt accession no.: P19525
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pThr446)
• Gene Information: human ... EIF2AK2(5610)

Description

Immunogen

Peptide sequence around phosphorylation site of threonine 446 (K-R-T(p)-R-S), according to the protein EIF2AK2.

Features and Benefits

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Target description

Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable