SAB4200298

Anti-Tensin 1 (internal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• Synonym(s): Anti-TNS, Anti-TNS1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 225 kDa (rat); antigen ~150 kDa (human)
• species reactivity: human, rat
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• concentration: ~1.5 mg/mL
• technique(s): western blot: 1-2 μg/mL using HEK-293T cells overexpressing human tensin1.; western blot: 1.5-3 μg/mL using lysates of A10 cells
• UniProt accession no.: Q9HBL0
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TNS1(7145) ; mouse ... Tns1(21961) ; rat ... Tns1(301509)

Description

General description

Tensin 1, also known as TNS1, is a member of tensin protein family. Tensins are multi domain proteins containing homologous C1, protein phosphatases (PTPases), C2, Src homology 2 (SH2) domains and pTyr-binding (PTB) domains. Tensin 1 mRNA is widely expressed in mouse embryo and various human adult tissues and is localized to focal adhesions.

Immunogen

synthetic peptide corresponding to a sequence located in the internal region of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.

Application

Anti-Tensin 1 (internal) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Tensins play an important role in regulating cell shape and motility. Tensin 1 is involved in organizing the actin cytoskeleton and mediating signal transduction. TNS1 is implicated in myofibroblast differentiation. In addition, it also helps myofibroblasts to form nascent fibronectin and collagen matrix.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable