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SAB3500873

Sigma-Aldrich

Monoclonal Anti-HEMAGGLUTININ antibody produced in mouse

clone 7B9B2, affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

7B9B2, monoclonal

form

buffered aqueous solution

species reactivity

virus

concentration

1 mg/mL

technique(s)

ELISA: suitable
immunoblotting: suitable

NCBI accession no.

AAT76166

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

General description

Hemagglutinin [Influenza A virus (A/chicken/Jilin/9/ 2004(H5N1))] is the principal surface antigen of influenza A virus. Hemagglutinin (HA) is a homotrimer; each monomer is a single polypeptide (HA0) that is post transcriptionally cleaved by host proteases into two subunits (HA1 and HA2). HA2 is highly conserved across different strains of influenza virus. HA preferentially binds to α2-3 sialic acid receptor in aves, whereas in human it binds to α2-6 sialic acid receptor.

Immunogen

Antibody was raised against a peptide corresponding to 13 amino acids in the middle of the Hemagglutinin protein.

Biochem/physiol Actions

Hemagglutinin (HA), specially HA2 is responsible for the binding of the virus to host receptors and enables its entry into the host cell through endocytosis through endosomal membrane fusion. HA is the primary target for neutralizing antibodies. HA is a potent target for drug and vaccine development.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection
Prabhu N, et al.
Journal of Virology, 83(6), 2553-2562 (2009)
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus.
Stevens J, et al.
Science, 312(5772), 404-410 (2006)
C Buxton Bridges et al.
The Journal of infectious diseases, 181(1), 344-348 (1999-12-23)
The first outbreak of avian influenza A (H5N1) occurred among humans in Hong Kong in 1997. To estimate the risk of person-to-person transmission, a retrospective cohort study was conducted to compare the prevalence of H5N1 antibody among health care workers
K F Shortridge et al.
Virology, 252(2), 331-342 (1999-01-08)
The transmission of avian H5N1 influenza viruses to 18 humans in Hong Kong in 1997 with six deaths established that avian influenza viruses can transmit to and cause lethal infection in humans. This report characterizes the antigenic and biological properties
D J Alexander
Veterinary microbiology, 74(1-2), 3-13 (2000-05-09)
Only type A influenza viruses are known to cause natural infections in birds, but viruses of all 15 haemagglutinin and all nine neuraminidase influenza A subtypes in the majority of possible combinations have been isolated from avian species. Influenza A
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