SAB1300669

Anti-SULT2B1a/b (N-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(s): Anti-Alcohol sulfotransferase, Anti-HSST2, Anti-Hydroxysteroid sulfotransferase SULT2B1b, Anti-Sulfotransferase family, cytosolic, 2B, member 1, isoform b
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): indirect ELISA: 1:1000; western blot: 1:100-1:500
• NCBI accession no.: NP_004596
• UniProt accession no.: O00204
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SULT2B1(6820)

Description

General description

Cytosolic sulfotransferases (STs or SULTs) encodes hydroxysteroid sulfotransferase (SULT2B1), the isoforms of which are SULT2B1a and SULT2B1b. By PCR with human placental and prostate cDNA as template, they isolated 2 alternatively spliced cDNAs, identical throughout most of their sequences, but having different 5-prime ends. The shorter cDNA, SULT2B1a, encodes a protein of 350 amino acids; the longer cDNA, SULT2B1b, encodes a 365-amino acid protein. Genomic PCR analysis revealed that the gene encoding both cDNAs, SULT2B1, contains 7 exons, with 2 alternative first exons being used to generate SULT2B1a and SULT2B1b. Northern blot analysis revealed that the SULT2B1 gene is expressed as a 1.4-kb transcript predominantly in prostate, placenta, and trachea. In human chromosome, the gene SULT2B1a/b is localized on 19q13.3.

Immunogen

SULT2B1A/B (NP_004596, 1-30)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SULT2B1a/b.

Biochem/physiol Actions

Cytosolic sulfotransferases (STs or SULTs) catalyse the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. SULT2B1 is involved in the synthesis and metabolism of steroids, which is essential for skin development and skin barrier function. Mutations in SULT2b1a/b gene leads to increased keratinocyte proliferation and altered cholesterol metabolism, resulting in autosomal-recessive congenital ichthyosis (ARCI). SULT2B1 catalyses the sulfation of an androgen precursor, dehydroepiandrosterone (DHEA) and hence polymorphism within this gene may lead to prostate tumor.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable