PZ0270

PF-05190457

≥95% (HPLC)

• Synonym(s): 1-[2-[(1R)-2,3-Dihydro-5-(6-methyl-4-pyrimidinyl)-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-ethanone, 2-(2-Methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-ylethanone, PF 5190457, PF-5190457
• Empirical Formula (Hill Notation): C₂₉H₃₂N₆OS
• CAS Number: 1334782-79-4
• Molecular Weight: 512.67
• MDL number: MFCD28411390
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823804

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• optical activity: [α]/D +40 to +60°, c = 0.5 in methanol
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: room temp
• SMILES string: CC1=CN2C(S1)=NC(CC(N3CCC4(CN([C@H](CCC5=C6)C5=CC=C6C7=NC=NC(C)=C7)C4)CC3)=O)=C2
• InChI: 1S/C29H32N6OS/c1-19-11-25(31-18-30-19)22-3-5-24-21(12-22)4-6-26(24)35-16-29(17-35)7-9-33(10-8-29)27(36)13-23-15-34-14-20(2)37-28(34)32-23/h3,5,11-12,14-15,18,26H,4,6-10,13,16-17H2,1-2H3/t26-/m1/s1
• InChI key: ZIUDADZJCKGWKR-AREMUKBSSA-N

Description

Biochem/physiol Actions

PF-05190457 is an orally available, potent and selective ghrelin receptor inverse agonist. PF-05190457 potently increases insulin secretion in glucose-stimulated human islets.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable