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Key Documents

PRS4003

Sigma-Aldrich

Anti-APH1 (ab2) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Anterior pharynx defective 1 homolog A (C. elegans), Anti-Presenilin stabilization factor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 29 kDa

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

Q96BI3

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APH1A(51107)

General description

APH1 (anterior pharynx defective-1) is a component of γ-secretase complex. It is located on chromosome 1q21. It has 2 unique isoforms such as APH1a, located on chromosome 1 and APH1b, located on chromosome 15 (3).

Immunogen

a 18 amino acid peptide from near the center of human APH1.

Biochem/physiol Actions

APH1 (anterior pharynx defective-1) participates in the secretase like activity. Throughout the embryonic development, APH1 participates in presenilin dependent function.

Linkage

The action of this antibody can be blocked using blocking peptide SBP4003.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin
Zhao G, et al.
The Journal of Neuroscience (2010)
Exploiting protein-protein interaction networks for genome-wide disease-gene prioritization
Guney E and Oliva B
PLoS ONE, 7(9) (2012)
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin
Zhao G, et al.
The Journal of Neuroscience, 30(5), 1648-1656 (2010)
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes
Pardossi-Piquard R, et al.
The Journal of Biological Chemistry, 284(24), 16298-16307 (2009)

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