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P9497

Sigma-Aldrich

Anti-Potassium Channel hKv11.1 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-Ether-a-go-go-related Channel, Anti-HERG

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About This Item

MDL number:
MFCD02097212
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

western blot: 1:400 using the lysate of HEK 293 cells, stably expressing HERG

UniProt accession no.

Q12809

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCNH2(3757)
mouse ... Kcnh2(16511)
rat ... Kcnh2(117018)

Immunogen

GST fusion protein with sequence corresponding to residues 1106-1159 of human KV11.1. The sequence is identical in rabbit and has 51/54, 50/54, and 50/54 residues identical in dog, mouse, and rat. Homology with related proteins: rat erg2 is 22/54 residues identical and rat erg3 is 21/54 residues identical.

Physical form

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.025% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Hazard Statements

H412

Precautionary Statements

P273

Hazard Classifications

Aquatic Chronic 3

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Clayton Whitmore et al.
Skeletal muscle, 10(1), 1-1 (2020-01-18)
Skeletal muscle atrophy is the net loss of muscle mass that results from an imbalance in protein synthesis and protein degradation. It occurs in response to several stimuli including disease, injury, starvation, and normal aging. Currently, there is no truly
J S Mitcheson et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(22), 12329-12333 (2000-09-27)
Mutations in the HERG K(+) channel gene cause inherited long QT syndrome (LQT), a disorder of cardiac repolarization that predisposes affected individuals to lethal arrhythmias [Curran, M. E. , Splawski, I., Timothy, K. W., Vincent, G. M., Green, E. D.
J I Vandenberg et al.
Trends in pharmacological sciences, 22(5), 240-246 (2001-05-08)
The K+ channel encoded by the human ether-à-go-go related gene (HERG) is one of many ion channels that are crucial for normal action potential repolarization in cardiac myocytes. HERG encodes the pore-forming subunit of the rapid component of the delayed

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